titel project

Scientific publications of TheSchistoVac:

Alterations in peripheral blood B cell subsets and dynamics of B cell
responses during human schistosomiasis
. Labuda LA1, Ateba-Ngoa
U, Feugap EN, Heeringa JJ, van der Vlugt LE, Pires RB, Mewono L, Kremsner
PG, van Zelm MC, Adegnika AA, Yazdanbakhsh M, Smits HH. PLoS Negl
Trop Dis. 2013;7(3):e2094. doi: 10.1371/journal.pntd.0002094.
Epub 2013 Mar 7.

Progressive cross-reactivity in IgE responses: an explanation for
the slow development of human immunity to schistosomiasis?

Fitzsimmons CM1, Jones FM, Pinot de Moira A, Protasio AV, Khalife J,
Dickinson HA, Tukahebwa EM, Dunne DW. Infect Immun.
2012 Dec;80(12):4264-70. doi: 10.1128/IAI.00641-12. Epub 2012 Sep 24.

Differential anti-glycan antibody responses in Schistosoma mansoni
-infected children and adults studied by shotgun glycan microarray.
van Diepen,
A., Smit, C.H., van Egmond, L., Kaba tereine, N.B., Pinot de Moira, A., Dunne D.W., Hokke C.H. PLoS Negl Trop Dis. 2012 Nov;6(11):e1922. doi: 10.1371/journal.pntd.0001922.

Assessment of the effect of Schistosoma haematobium co infection malaria parasites and immune responses in rural populations in Gabon: study protocol.
Ateba Ngoa U, Zinsou JF, Kassa RF, Ngoune Feugap E, Honkpehedji YJ, Massinga-Loembe M3, Kenguele Moundounga H, Nkoma Mouima AM, Mbenkep LH, Wammes LJ, Mbow M, Kruize Y, Mombo-Ngoma G, Bouyoukou Hounkpatin AL, Dejon Agobe JC, Saadou I, Lell B, Smits H, Kremsner PG, Yazdanbakhsh M, Adegnika AA. Springerplus.
2014 Jul 29;3:388. doi: 10.1186/2193-1801-3-388. eCollection 2014.

Impact of short-time urine freezing on the sensitivity of an established Schistosoma real-time PCR assay. Kenguele HM, Adegnika AA, Nkoma AM, Ateba-Ngoa U, Mbong M, Zinsou J, Lell 2, Verweij JJ2. Am J Trop Med Hyg.
2014 Jun;90(6):1153-5. doi: 10.4269/ajtmh.14-0005. Epub 2014 Apr 7.

Interleukin 10 (IL-10)-Producing CD1dhi Regulatory B Cells From Schistosoma Haematobium-Infected Individuals Induce IL-10-Positive T Cells and Suppress Effector T-Cell Cytokines. van der Vlugt LE1, Zinsou JF2, Ozir-Fazalalikhan A1, Kremsner PG3, Yazdanbakhsh M1, Adegnika AA4, Smits HH1.
J Infect Dis. 2014 May 1. pii: jiu257. [Epub ahead of print]

Randomized, controlled, assessor-blind clinical trial to assess the efficacy of single- versus repeated-dose albendazole to treat ascaris lumbricoides, trichuris trichiura, and hookworm infection. Adegnika AA, Zinsou JF, Issifou S, Ateba-Ngoa U, Kassa RF, Feugap EN, Honkpehedji YJ, Dejon Agobe JC, Kenguele HM, Massinga-Loembe M, Agnandji ST, Mordmüller B, Ramharter M, Yazdanbakhsh M, Kremsner PG, Lell B. Antimicrob Agents Chemother. 2014 May;58(5):2535-40. doi: 10.1128/AAC.01317-13. Epub 2014 Feb 18.

Molecular diagnosis of Schistosoma infections in urine samples of school children in Ghana. Aryeetey YA, Essien-Baidoo S, Larbi IA, Ahmed K, Amoah AS, Obeng BB, van Lieshout L, Yazdanbakhsh M, Boakye DA, Verweij JJ. Am J Trop Med Hyg. 2013 Jun;88(6):1028-31. doi: 10.4269/ajtmh.12-0571. Epub 2013 Mar 25.


Scientific background of the project:

Phenotype and function of human T lymphocyte subsets: consensus and issues. Appay, V., R.A. van Lier, F. Sallusto, and M. Roederer. 2008. Cytometry A. 73:975-83.

Studies on the surface antigenicity and susceptibility to antibody-dependent killing of developing schistosomula using sera from chronically infected mice and mice vaccinated with irradiated cercariase. Bickle QD, Ford MJ. 1982. J. Immunol. 128:2101-6.

Regulatory B cells as inhibitors of immune responses and inflammation. Bouaziz, J.D., K. Yanaba, and T.F. Tedder. 2008. Immunol Rev. 224:201-14.

Immunity in human Schistosomiasis mansoni: cross-reactive IgM and IgG2 anticarbohydrate antibodies block the expression of immunity. Butterworth, A., D. Dunne, A. Fulford, M. Capron, J. Khalife, A. Capron, D. Koech, J. Ouma, and R. Sturrock 1988. Biochimie 70:1053-63.

Rats, mice and men models for immune effector mechanisms againstschistosomiasis. Capron, M., and A. Capron. 1986. Parasitol Today. 2:69-75.

Eosinophil-dependent cytotoxicity in rat schistosomiasis. Involvement of IgG2a antibody and role of mast cells. Capron M, Capron A, Torpier G, et al. 1978. Eur J Immunol 8:127-33.

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Darrah, P.A., D.T. Patel, P.M. De Luca, R.W. Lindsay, D.F. Davey, B.J. Flynn, S.T. Hoff, P. Andersen, S.G. Reed, S.L. Morris, M. Roederer, and R.A. Seder. 2007. Nat Med. 13:843-50.

General microarray technique for immobilization and screening of natural glycans. De Boer AR, Hokke CH, Deelder AM, Wuhrer M. 2007. Anal Chem. 79:8107-13.

Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposure. Fitzsimmons, C.M., R. McBeath, S. Joseph, F.M. Jones, K. Walter, K.F. Hoffmann, H.C. Kariuki, J.K. Mwatha, G. Kimani, N.B. Kabatereine, B.J. Vennervald, J.H. Ouma, and D.W. Dunne. 2007. Int Arch Allergy Immunol. 142:40-50.

Proteomic analysis of skin invasion by blood fluke larvae. Hansell, E., S. Braschi, K.F. Medzihradszky, M. Sajid, M. Debnath, J. Ingram, K.C. Lim, and J.H. McKerrow. 2008. PLoS Negl Trop Dis. 2:e262.

Glycomics-driven discoveries in schistosome research. Hokke CH, Deelder AM, Hoffmann KF, Wuhrer M 2007. Exp Parasitol. 2007 117:275-83.

Adult resistance to schistosomiasis mansoni: age-dependence of reinfection remains constant in communities with diverse exposure patterns. Kabatereine, N.B., B.J. Vennervald, J.H. Ouma, J. Kemijumbi, A.E. Butterworth, D.W. Dunne, and A.J. Fulford. 1999. Parasitology. 118 ( Pt 1):101-5.

Mechanisms of resistance to S. mansoni infection: the rat model. Khalife, J., C. Cêtre, C. Pierrot, and M. Capron. 2000. Parasitology International. 49:339-345.

Functional role of human IgG subclasses in eosinophil-mediated killing of schistosomula of Schistosoma mansoni. Khalife, J., D.W. Dunne, B.A. Richardson, G. Mazza, K.J. Thorne, A. Capron, and A.E. Butterworth. 1989. J Immunol. 142:4422-7.

The unacknowledged impact of chronic schistosomiasis. King, C.H., and M. Dangerfield-Cha. 2008. Chronic Illn. 4:65-79.

Proteomic analysis of Schistosoma mansoni cercarial secretions. Knudsen, G.M., K.F. Medzihradszky, K.C. Lim, E. Hansell, and J.H. McKerrow. 2005. Mol Cell Proteomics. 4:1862-75.

Coordination of early protective immunity to viral infection by regulatory T cells. Lund JM, Hsing L, Pham TT, Rudensky AY. 2008. Science. 2008 320:1220-4.

The immunobiology of schistosomiasis. Pearce EJ, MacDonald AS. 2002. Nat Rev Immunol. 2:499-511.

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. Moir, S., J. Ho, A. Malaspina, W. Wang, A.C. DiPoto, M.A. O'Shea, G. Roby, S. Kottilil, J. Arthos, M.A. Proschan, T.W. Chun, and A.S. Fauci. 2008. J Exp Med. 205:1797-805.

Schistosomes in the skin: a balance between immune priming and regulation. Mountford, A.P., and F. Trottein. 2004. Trends Parasitol. 20:221-6.

The development of schistosomiasis mansoni in an immunologically naive immigrant population in Masongaleni, Kenya. Ouma, J.H., A.J. Fulford, H.C. Kariuki, G. Kimani, R.F. Sturrock, G. Muchemi, A.E. Butterworth, and D.W. Dunne. 1998. Parasitology. 117 ( Pt 2):123-32.

Priming of the immune response by schistosome eggs. Pearce, E.J. 2005. Parasite Immunol. 27:265-70.

Two new trifunctional antibodies for the therapy of human malignant melanoma. Ruf, P., M. Jager, J. Ellwart, S. Wosch, E. Kusterer, and H. Lindhofer. 2004. Int J Cancer. 108:725-32.

Associations between specific antibody responses and resistance to reinfection in a Senegalese population recently exposed to Schistosoma mansoni. Vereecken, K., C.W. Naus, K. Polman, J.T. Scott, M. Diop, B. Gryseels, and L. Kestens. 2007. Trop Med Int Health. 12:431-44.